Pengrong Yan, PhD Research Scholar
Contact
Mentor
Dr. Gutian Xiao
Dissertation
Education
PhD in Biochemistry and Molecular Genetics, University of Pittsburgh, School of Medicine, 2010
BS in Biological Sciences, School of Life Sciences, Fudan University (China), 2005
Why I chose Pitt
School of Medicine offers professional mentors and collaborative research environment. You will never regret to be a member of University of Pittsburgh and a loyal fan of Panthers and Steelers.
Currently, Dr. Yan is a Research Scholar at the Memorial Sloan-Kettering Cancer Center. He is integrating his knowlegde in cancer signaling biology into using pharmacological agents to determine the oncogenic mechanisms and understand the modulation of chaperones in cancer cell development.
Publications
The tumor suppressor gene WWOX links the canonical and noncanonical NF-kappaB pathways in HTLV-I Tax-mediated tumorigenesis. Blood. 117: 1652-1661. | View Abstract
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 70: 1766-1772. | View Abstract
Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J Biol Chem. 285: 11786-117892. | View Abstract
Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis. Oncogene. 29: 6499-6507. | View Abstract
Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. Neoplasia. 11: 1036-1041. | View Abstract
PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood. 113: 4370-4380. | View Abstract
Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions. Autophagy. 3: 600-603. | View Abstract
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